Figure 7.
Working model of PCIF1-mediated m6Am modification on BICD2 mRNA to regulate ciliogenesis. PCIF1 modifies m6Am on BICD2 mRNA, leading to reduced mRNA stability and translation, which suppresses BICD2 protein expression to inhibit ciliogenesis in mammalian cells.

Working model of PCIF1-mediated m 6 Am modification on BICD2 mRNA to regulate ciliogenesis. PCIF1 modifies m6Am on BICD2 mRNA, leading to reduced mRNA stability and translation, which suppresses BICD2 protein expression to inhibit ciliogenesis in mammalian cells.

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