Direct centriole transport in invertebrates. (A) In the early interphase, Drosophila neuroblasts establish asymmetric pericentriolar material (dark green) distribution around the two centrioles (red and pink). The mother centriole (red) interacts with Kinesin-1 (orange) which then moves it in a plus end–directed manner along the microtubule network. As the cell approaches prophase, the centriole stops moving on the microtubule network and recruits pericentriolar material for bipolar spindle formation (not illustrated here). (B) After an extension of the C. elegans’ sensory neuronal dendrite, one of the two neuron centrioles (pink) migrates along the microtubule network from the cell body to the distal tip of the axon where it forms the sensory cilium (green). The centriole migrates via an interaction with the minus end–directed microtubule motor Dynein (purple). +/− indicates microtubule polarity.