Centrosome translocation in interphase cells. (A) During cytokinesis of cultured cancer cells, the mother centriole (red) migrates (arrow) into the cytokinetic furrow along the midbody microtubules. Upon abscission, the centriole exits the cytokinetic furrow. (B) Upon interaction between lymphocytes and antigen-presenting cells, centrosomal actin (light blue) disassembles and dynein (purple) clusters at the immune synapse. Microtubule nucleation at the centrosome is increased and these centrosomal microtubules (black) contact the clustered dynein motors, which then pull on the microtubules to move the centrosomes to the center of the immune synapse. +/− indicates microtubule polarity.