α-Family karyopherins recognize and bind to the WW-NLS. (A–F) The structures from PDB or AlphaFold DB exhibit the positions of PPxY/F and xPxPP motifs on KPNA2 (A), KPNA3 (B), KPNA4 (C), KPNA5 (D), KPNA6 (E), and KPNA7 (F) in an open state, respectively.