S2808A and S2030A; NND and CDF with and without Iso . (A and B) NNDs of RyR2 were acquired from S2808A (A) and S2030A (B) mice hearts, (i) saline-perfused and (ii) treated with ISO. CDF of tetramer NND acquired from (A iii) S2808A and (B iii) S2030A hearts perfused with saline or Iso compared to their WT.