NND and CDF of WT mice with and without Iso; CDF of rat, human, and WT mice . (A and B) NNDs of RyR2 were acquired from WT S2030_S2808 (A) and WT 2814 (B) mice, (i) at rest and (ii) from mice whose hearts had been treated with ISO. (C) CDF of tetramer NND acquired from WT mice hearts perfused with saline and from those treated with ISO. (D) CDF of tetramer NND comparing WT mice with rats and humans.