Figure 9.

Elm1 stabilizes Gin4 at the bud neck prior to cytokinesis. (A) Maximum-intensity projection images of representative YEF10559 (elm1∆ GIN4-GFP CDC3-mCherry mRuby2-TUB1) cells from a time-lapse series taken with a 2-min interval with Gin4-GFP in green at indicated times. T = 0 is mitotic spindle break. Gray dashed line is the cell periphery. Yellow boxed region is the area used for measurements in B and D and to make montages for C. Scale bar = 2 μm. (B) Quantification of Gin4-GFP signal from cells in A and C. Shown is integrated measured background subtracted intensity of Gin4-GFP in WT (dark green) and elm1∆ (light green) cells from the sum projection of given number cells for each strain. The mean is plotted with error bars being the SD. a.u. = arbitrary units. (C) Montages of representative YEF10558 (GIN4-GFP CDC3-mCherry mRuby2-TUB1) and YEF10559 (elm1∆ Gin4-GFP Cdc3-mCherry mRuby2-TUB1) cells showing maximum-intensity projections from 20 min before to 10 min after mitotic spindle break from time-lapse series taken with a 2-min interval. T = 0 is mitotic spindle break. Scale bars = 1 μm. (D) Quantification of Gin4-GFP signal from cells in A and C. Shown is background subtracted intensity relative to the maximum value measured of Gin4-GFP in WT (dark green) and elm1∆ (light green) cells from the sum projection of given number cells for each strain. The mean is plotted with error bars being the SD.

or Create an Account

Close Modal
Close Modal