EKP-specific regulons expression and EZH2 downstream targeted genes expression. (A) The expression of 20 regulons in TCGA DGAC patients and normal stomach. (B) Regulon activity based UMAP of Gtf2b, Pole4, and Sox4. P values were calculated by using the Student’s t test; error bars: SD. (C and D) Feature plots of EZH2 downstream target genes (C, genes which are downregulated by EZH2 through histone modification; D, genes which are downregulated by EZH2 reported in gastric cancer) scores in the epithelial cells of DGAC1 and DGAC2. Gene list of EZH2 targeted genes was listed in Table S9. ns: P > 0.05; *: P ≤ 0.05; **: P ≤ 0.01; ***: P ≤ 0.001. All data are derived from two or more independent experiments with the indicated number of samples.
Figure S5.

EKP-specific regulons expression and EZH2 downstream targeted genes expression. (A) The expression of 20 regulons in TCGA DGAC patients and normal stomach. (B) Regulon activity based UMAP of Gtf2b, Pole4, and Sox4. P values were calculated by using the Student’s t test; error bars: SD. (C and D) Feature plots of EZH2 downstream target genes (C, genes which are downregulated by EZH2 through histone modification; D, genes which are downregulated by EZH2 reported in gastric cancer) scores in the epithelial cells of DGAC1 and DGAC2. Gene list of EZH2 targeted genes was listed in Table S9. ns: P > 0.05; *: P ≤ 0.05; **: P ≤ 0.01; ***: P ≤ 0.001. All data are derived from two or more independent experiments with the indicated number of samples.

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