NR-V04 induces NR4A1 degradation. (A) NR-V04 effectively promoted the degradation of NR4A1 in two human melanoma cell lines within 16 h, CHL-1 (DC50 = 228.5 nM) and A375 (DC50 = 518.8 nM), while simultaneously stabilizing VHL protein; two experiments. (B) Celastrol treatment did not result in any significant change in the expression level of NR4A1 in the CHL-1 cell line within 16 h; two experiments. (C) Time-dependent degradation of NR4A1. CHL-1 cells were treated with 500 nM of NR-V04 at the indicated time points; two experiments. (D) NR-V04 did not induce the degradation of NR4A2 and NR4A3; two experiments. Source data are available for this figure: SourceData F4.
Figure 4.

NR-V04 induces NR4A1 degradation. (A) NR-V04 effectively promoted the degradation of NR4A1 in two human melanoma cell lines within 16 h, CHL-1 (DC50 = 228.5 nM) and A375 (DC50 = 518.8 nM), while simultaneously stabilizing VHL protein; two experiments. (B) Celastrol treatment did not result in any significant change in the expression level of NR4A1 in the CHL-1 cell line within 16 h; two experiments. (C) Time-dependent degradation of NR4A1. CHL-1 cells were treated with 500 nM of NR-V04 at the indicated time points; two experiments. (D) NR-V04 did not induce the degradation of NR4A2 and NR4A3; two experiments. Source data are available for this figure: SourceData F4.

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