NR4A1 deletion leads to diminished tumor growth. (A–C) Primary tumor growth curve in littermates of WT or NR4A1^−/− mice, including (A) MC38 colon cancer (P < 0.0001, four mice per group in one experiment); (B) Yummer1.7 melanoma (P < 0.000, eight mice per group in one experiment); and (C) B16F10 melanoma (P < 0.0001, five mice per group in one experiment). Two-way ANOVA was performed for all tumor growth curves with P values indicated.