Scheme 5, A–C , simulations of channel state occupancy. (A–C) Open channel occupancies simulated using Scheme 5 A (psQ+E1, A), 5 B (psQQ*+E1, B), and 5 C (EQ+QQ*Q*+E1, C) models using transition kinetics from Table 2, line 10, during a 5 s pulse from −140 to +80 mV, followed by a 1-s step to −40 mV. Number of channels is shown as a percentage of the total in the simulation, which also includes channels remaining in closed states (not shown). (D–F) As in A–C, except pulse was 0 mV. Legend colors in A–C also apply to D–F.