Structural model of K _V 7.2 derived from the cryo-EM structure 7CR3. (A) Full view of the tetrameric model embedded in a POPC bilayer (phosphate group depicted as tan spheres). One of the subunits is highlighted in green. (B and C) Detailed side (B) and top (C) views of VSD’s backbone from the highlighted subunit in A. Residues E130 and R198 are depicted as van der Waals spheres.