Figure 6.
Activation voltage dependence and deactivation kinetics of the mutants R198K and R198Q. (A and B) ITAIL–VACT plots generated from K+-currents recorded from oocytes expressing the mutants R198K (A) and R198Q (B) at pHEXT ranging from 6.0 to 8.0. (C and D). Deactivation average time constant (τDEACT) for the mutants R198K (n = 8) (C) and R198Q (D) also at pHEXT 6.0 through 8.0. Statistical test performed using the WT as reference. T test confidence intervals are color-coded; n = 8 for pHEXT 6.0, n = 11 for pHEXT 7.0, n = 12 for pHEXT 7.4, and n = 7 for pHEXT 8.0.

Activation voltage dependence and deactivation kinetics of the mutants R198K and R198Q. (A and B) ITAIL–VACT plots generated from K+-currents recorded from oocytes expressing the mutants R198K (A) and R198Q (B) at pHEXT ranging from 6.0 to 8.0. (C and D). Deactivation average time constant (τDEACT) for the mutants R198K (n = 8) (C) and R198Q (D) also at pHEXT 6.0 through 8.0. Statistical test performed using the WT as reference. T test confidence intervals are color-coded; n = 8 for pHEXT 6.0, n = 11 for pHEXT 7.0, n = 12 for pHEXT 7.4, and n = 7 for pHEXT 8.0.

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