Figure S1.
![CaV1.3 DI–DIV SF mutations minimally perturb channel activation. (A) Normalized current–voltage relationship for WT CaV1.3. Each dot, mean ± SEM n = 5 cells. (B–E) Normalized IV relations for DI W[+2]A (panel B, n = 5 cells), DII W[+2]A (panel C, n = 6 cells), DIII W[+2]A (panel D, n = 5 cells), and DIV W[+2]A (panel E, n = 7 cells) mutants. In all cases, the change in channel half-activation potential (V1/2) was <5 mV.](https://cdn.rupress.org/rup/content_public/journal/jgp/156/2/10.1085_jgp.202313365/1/jgp_202313365_figs1.png?Expires=1773453490&Signature=Nio-XJtj6fNqToTPgKAeMlf1v1Usni0aL1Ob3bRPaKHBxM-pnKFAiYokw95QUFs~6Wyx5-y5QP1~SBA6S-tGcsMbb9zWCfmCuJn4jhDxwiyV3Myicii3l-7ddAUJ3EnY1WzOHqNTrUwAISC0Y~dFhp69opRyhgPjlfp~tIu9vGQEJ8XUpmCbqMbjDopEemdK-AKyNaYS6BKEP4sXdn8a2wFsyXiw1BC68cyh7ZVnJw~rIAGaWtoJ7QKjgVIxpbLxKWU2YUjLbX4JiP-mmXb-0h30dDsg5BV7t174Ghs5-U3233-ORFSCjZRdITFBkbAeAhBmpAlT0XOcsf87y6em1A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ca V 1.3 DI–DIV SF mutations minimally perturb channel activation. (A) Normalized current–voltage relationship for WT CaV1.3. Each dot, mean ± SEM n = 5 cells. (B–E) Normalized IV relations for DI W[+2]A (panel B, n = 5 cells), DII W[+2]A (panel C, n = 6 cells), DIII W[+2]A (panel D, n = 5 cells), and DIV W[+2]A (panel E, n = 7 cells) mutants. In all cases, the change in channel half-activation potential (V1/2) was <5 mV.