Figure S2. Effect of adenosine and Mg 2... | Rockefeller University Press

Figure S2.

Effect of adenosine and Mg2+on the activated RyR2 channel from RyR2-expressing HEK293 cells. The effect of adenosine and following addition of Mg2+ on Po for RyR2 derived from HEK293 cells expressing RyR2-only. The traces were recorded in symmetrical 210 mM KPIPES with 2 µM free Ca2+, pH 7.2, at the holding potential of −30 mV, with treatments shown in the figure. One-way ANOVA gives significant differences with P < 0.0001 (n = 3). Adjusted P values (Tukey’s correction) used for multiple comparisons are labeled above each pair of comparison if there is significant difference. Values are of the mean ± SEM.

Effect of adenosine and Mg ²⁺ on the activated RyR2 channel from RyR2-expressing HEK293 cells. The effect of adenosine and following addition of Mg²⁺ on Po for RyR2 derived from HEK293 cells expressing RyR2-only. The traces were recorded in symmetrical 210 mM KPIPES with 2 µM free Ca²⁺, pH 7.2, at the holding potential of −30 mV, with treatments shown in the figure. One-way ANOVA gives significant differences with P < 0.0001 (n = 3). Adjusted P values (Tukey’s correction) used for multiple comparisons are labeled above each pair of comparison if there is significant difference. Values are of the mean ± SEM.

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