Effect of coexpressing TRIC-A or TRIC-B with RyR2 on the reversal potential. The mean E_rev values obtained after the application of a voltage ramp are compared for RyR2+TRIC-A (blue squares; n =11) and RyR2+TRIC-B (red triangles; n = 13) vesicle preparations. Ramp currents were recorded in triplicates for each bilayer experiment and the three E_revs measured were averaged and plotted as a single data point. An unpaired t test gives P = 0.0055, indicated by **. Symbols indicate values from individual experiments and bars indicate mean ± SEM.