Prediction of the Pax5 protein structure by AlphaFold. The machine learning method AlphaFold (Jumper et al., 2021) correctly identified the structure of the bipartite paired domain of Pax5 that was previously defined by x-ray crystallography (Garvie et al., 2001). AlphaFold newly predicts α-helical structures for the OP and HD and furthermore indicates that the C-terminal transactivation and inhibitory domains of Pax5 (Dörfler and Busslinger, 1996) are unstructured. The C-terminal domains are referred to as CRD1 and CRD2 in this publication.