Figure S6.
NaV1.2 variants affect channel inactivation. (A and B) Average deviation from WT NaV1.2A for (A) persistent current and (B) frequency-dependent channel rundown at 20 Hz. Data are plotted as mean ± 95% CI. (C and D) Volcano plots highlighting variants significantly different from WT for (C) persistent current and (D) frequency-dependent rundown. Red symbols denote LoF and blue symbols denote GoF with P < 0.05 (n = 5–103). Data were collected from two to four separate 384-well automated patch clamp experiments, and statistical comparisons were performed using a Kruskal–Wallis test followed by Dunn’s post-hoc test for multiple comparisons. Exact P values are presented in Tables S3 and S4.

Na V 1.2 variants affect channel inactivation. (A and B) Average deviation from WT NaV1.2A for (A) persistent current and (B) frequency-dependent channel rundown at 20 Hz. Data are plotted as mean ± 95% CI. (C and D) Volcano plots highlighting variants significantly different from WT for (C) persistent current and (D) frequency-dependent rundown. Red symbols denote LoF and blue symbols denote GoF with P < 0.05 (n = 5–103). Data were collected from two to four separate 384-well automated patch clamp experiments, and statistical comparisons were performed using a Kruskal–Wallis test followed by Dunn’s post-hoc test for multiple comparisons. Exact P values are presented in Tables S3 and S4.

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