Figure 3.
Membrane constriction and scission steps of peroxisomal and mitochondrial division. Color scheme for protein domains is as shown in Fig. 1. Pex11 is involved in membrane tubulation during PO division, while Fis1/FIS1, Mdv1, MFF, and MiD49/51 recruit Dnm1/DRP1 for membrane scission. In mitochondria, the hydrolase domain of ABHD16A and ER tubules helped by actin cause membrane constriction of mitochondria. The hydrolase of ABHD16A facilitates membrane lipid remodeling by the conversion of PS to lyso-PS, while the acyltransferase domain of this protein facilitates assembly of the mitochondrial fission (and fusion) machinery (Nguyen and Voeltz, 2022). Patches of the lipid CL activate DRP1 (Bustillo-Zabalbeitia et al., 2014), which is assembled at mitochondrial membrane constriction sites using FIS1, MFF, MiD49 and MiD51.

Membrane constriction and scission steps of peroxisomal and mitochondrial division. Color scheme for protein domains is as shown in Fig. 1. Pex11 is involved in membrane tubulation during PO division, while Fis1/FIS1, Mdv1, MFF, and MiD49/51 recruit Dnm1/DRP1 for membrane scission. In mitochondria, the hydrolase domain of ABHD16A and ER tubules helped by actin cause membrane constriction of mitochondria. The hydrolase of ABHD16A facilitates membrane lipid remodeling by the conversion of PS to lyso-PS, while the acyltransferase domain of this protein facilitates assembly of the mitochondrial fission (and fusion) machinery (Nguyen and Voeltz, 2022). Patches of the lipid CL activate DRP1 (Bustillo-Zabalbeitia et al., 2014), which is assembled at mitochondrial membrane constriction sites using FIS1, MFF, MiD49 and MiD51.

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