Figure 4.

Representative poses of a LIN-Gly and LIN-Tyr constant binders at previously described Sites Iα and Iβ and Site II. Site I was split into Site Iα and β to better show the two major but different confirmations of PUFAs at Site I. We have previously published this separation of Site I into Site Iα and β in Yazdi et al. (2021). Red residues are making head group interactions with the PUFAs. (A) Side view of representative LIN-Gly constant binder at Sites Iα, Iβ, and II. (B) Overlay of all LIN-Gly constant binder poses at Sites Iα, Iβ, and II. The LIN-Gly head group is shown in red and the tail in green. (C) Side view of representative LIN-Tyr constant binder at Sites Iβ and II. (D) Overlay of all LIN-Tyr constant binder poses at Sites Iβ and II. The LIN-Tyr head group is shown in red and the tail in blue.

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