Figure 5.
TZD-induced changes in single-channel lifetime and appearance frequency. Relative changes in gA−(13) (red squares) and AgA(15) (blue circles) channel lifetimes as a function of [TZD], normalized to the lifetimes before TZD addition for: (A) troglitazone (TRO), (B) rosiglitazone (ROS), (C) pioglitazone (PIO), and (D) ciglitazone (CIG; n = 4–7). The appearance frequency after is normalized to the appearance frequency before the addition of the TZD: (E) 1 µM troglitazone (TRO), (F) 30 µM rosiglitazone (ROS), (G) pioglitazone (PIO), and (H) ciglitazone (CIG; n = 2–4).