Effects of TZDs on ion permeation and single-channel lifetimes. Current transition amplitude histograms for gA⁻(13) and AgA(15) channels before (control) and after the addition of: (A) 6 µM troglitazone (TRO) and (B) 6 µM ciglitazone (CIG). The vertical lines denote the single-channel current transition amplitudes in the absence of the TZD for gA⁻(13) (red line) and AgA(15) (blue line). Single-channel survivor histograms for gA⁻(13) (red line) and AgA(15) (blue line) channels in the presence of varying concentrations of: (C) troglitazone (TRO) and (D) ciglitazone (CIG). Each plot was fitted with a single-exponential distribution (dashed gray lines); the average lifetimes (τ) for each TZD and concentration are indicated in the panels.