Figure 1.
Figure 1. TZD structures. The TZDs are hydrophobic, with octanol–water clogP values (calculated from the experimental logD7.4) and logD7.4 (experimental) of: 5.3 and 4.2 for troglitazone, 2.8 and 2.6 for rosiglitazone, 3.3 and 3.1 for pioglitazone, and 5.7 and 4.6 for ciglitazone (Giaginis et al., 2007). Calculated pKa is 6.4 (±0.5) for all of the TZDs (Giaginis et al., 2007). Structures were drawn using MarvinSketch 5.0.3 (ChemAxon).

TZD structures. The TZDs are hydrophobic, with octanol–water clogP values (calculated from the experimental logD7.4) and logD7.4 (experimental) of: 5.3 and 4.2 for troglitazone, 2.8 and 2.6 for rosiglitazone, 3.3 and 3.1 for pioglitazone, and 5.7 and 4.6 for ciglitazone (Giaginis et al., 2007). Calculated pKa is 6.4 (±0.5) for all of the TZDs (Giaginis et al., 2007). Structures were drawn using MarvinSketch 5.0.3 (ChemAxon).

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