The rate and extent of current decay is correlated to conductance and current amplitude. (A) Computed currents, as for Fig. 8 A, but with the indicated concentrations of GABA applied for 2.5 s. (B) Currents as in A, but normalized to peak current to facilitate comparison of decay rate. Note the faster decay at higher GABA concentration. (C) Currents as in B, but with 1.0 mM GABA applied for 10 s, and with a variable maximum conductance. The maximum conductance for each trace is given relative to the mean conductance (54 nS) experimentally observed at 1.0 mM GABA. (D) Relation between decay time constant, residual current after 10 s in GABA, and the peak (absolute) current for computations similar to those used for C. No true desensitization included in the model (A–C).