Variations in the Kv1.3/Kv1.5 ratio correlate with changes in biophysical properties of K+ currents in macrophages. (A) Kv1.3/Kv1.5 ratios in Raw cells cultured in the presence or absence of LPS and DEX were calculated from real-time PCR experiments in Fig. 4 and standardized to the value of control cells. Values are the mean ± SEM of at least three independent experiments. *, P < 0.05 versus control (Student’s t test). (B) Percentage of MgTx inhibition plotted against the Kv1.3/Kv1.5 ratio. (C) Time constant of inactivation from Fig. 4 (τ) plotted against the Kv1.3/Kv1.5 ratio. (D) Percentage of cumulative inactivation plotted against the Kv1.3/Kv1.5 ratio. The Pearson product-moment correlation coefficient using a two-tailed p-value was calculated (P < 0.0393, P < 0.0355, and P < 0.0116 for A, B, and C, respectively). White (bar or circle), control; black (bar or circle), LPS; gray (bar or circle), DEX.
