Figure 3.
![Figure 3. Illustration of all the possible ways that the seven binding sites on the (PA63)7 channel can be occupied by LFN. The ring of seven gray circles represents the (PA63)7 channel, and the black oval represents LFN. Note that when LFN is bound to the channel, it occupies two adjacent subunits. kon is the rate constant for binding of LFN to two subunits, and koff is the dissociation rate. (kon is directly proportional to the concentration of LFN.) The arrows indicate the binding and unbinding transitions between each of the states. [0], [1], [2], and [3] are the fractions of channels occupied by zero, one, two, and three LFNs, respectively.](https://cdn.rupress.org/rup/content_public/journal/jgp/137/6/10.1085_jgp.201110627/5/jgp_201110627_gs_fig3.jpeg?Expires=1767745315&Signature=ndWPNPCkQSPkH3qZo7OE7If2ayLrOdkvpT-Y3toYvfsxJELdSL4EnedGPCqewgC94c5NMTmBWmZU~3EBTDJuc7VuG2uTdFumxHFEzE1KPDK-Q8Pzd0Oc2pm7LiSeXwspikPvMNJhTChl-MWw50pPlfsPAHKDDh7Iiw20Cl7D11tlSUXu-bc0A4aPO4DMrjBEzUQ8wT0RTQskw5ZQxIF7P1hw8jDur4P-iJWwesZhilPmVuwBav1FKA~G8Cf2mohE~1H-311UCYFoJbOaNi3hBG595OWRybpqcVQh6WRo~J8qxKxu9sVXU9vFQrp5VnVxLX~OXFtRxspE25x3MRBIZQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Illustration of all the possible ways that the seven binding sites on the (PA63)7 channel can be occupied by LFN. The ring of seven gray circles represents the (PA63)7 channel, and the black oval represents LFN. Note that when LFN is bound to the channel, it occupies two adjacent subunits. kon is the rate constant for binding of LFN to two subunits, and koff is the dissociation rate. (kon is directly proportional to the concentration of LFN.) The arrows indicate the binding and unbinding transitions between each of the states. [0], [1], [2], and [3] are the fractions of channels occupied by zero, one, two, and three LFNs, respectively.
