Figure 1.

Structure of the (PA63)7 channel. The figure on the left was created from the PA channel atomic model (Protein Data Bank accession no. 1V36) reported by Nguyen (2004). The parallel dashed lines indicate the thickness of the hydrophobic interior of the phospholipid bilayer. The figure on the right is a top view of this structure. The three black outlines are LFNs and are placed where they are presumed to bind to the mushroom cap of the channel (Melnyk et al., 2006). Note that even though there are seven binding sites in the cap, only three LFNs can be accommodated.

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