Figure 9. Effects of acidic pHi on TRPM2 whole cell currents. (A) TRPM2 currents recorded at pHi 7.2, 6.5, and 5.5. Note that there was a delay for activation of TRPM2 at pHi 6.5, and a much longer delay for TRPM2 activation at pHi 5.5. (B) Typical I-V relationship of TRPM2 whole cell current at different pHis. (C) The inhibitory effect of pHi 5.5 on TRPM2 was reversed by perfusing the cells with extracellular solutions containing 30 mM NH4Cl. (D) Representative recordings of TRPM2 in the presence of NH4Cl. NH4Cl increased both inward and outward currents of TRPM2.
Figure 9.

Effects of acidic pHi on TRPM2 whole cell currents. (A) TRPM2 currents recorded at pHi 7.2, 6.5, and 5.5. Note that there was a delay for activation of TRPM2 at pHi 6.5, and a much longer delay for TRPM2 activation at pHi 5.5. (B) Typical I-V relationship of TRPM2 whole cell current at different pHis. (C) The inhibitory effect of pHi 5.5 on TRPM2 was reversed by perfusing the cells with extracellular solutions containing 30 mM NH4Cl. (D) Representative recordings of TRPM2 in the presence of NH4Cl. NH4Cl increased both inward and outward currents of TRPM2.

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