Figure 6.
Figure 6. The dynamics of Gm during AP firing in rat EDL muscle fibers reflect regulation of ClC-1 and KATP ion channels. (A) Mean Gm from 13 fibers in the presence of 100 µM 9-AC and 10 nM TTX. (B) Mean Gm from experiments at 127 (n = 13) or 50 mM Cl− (n = 16) in the presence of 10 µM of the KATP channel inhibitor glibenclamide. (C) From the recordings in B, GK and GCl in the presence of glibenclamide were calculated using Eq. 4. (D) Mean Gm from six experiments in which the mitochondrial KATP channels were inhibited using 5-HD. Under all conditions, Gm recovered fully within 1 min after cessation of AP firing (not depicted). Mean data are presented with every fifth error bar (mean ± SEM).

The dynamics of Gm during AP firing in rat EDL muscle fibers reflect regulation of ClC-1 and KATP ion channels. (A) Mean Gm from 13 fibers in the presence of 100 µM 9-AC and 10 nM TTX. (B) Mean Gm from experiments at 127 (n = 13) or 50 mM Cl− (n = 16) in the presence of 10 µM of the KATP channel inhibitor glibenclamide. (C) From the recordings in B, GK and GCl in the presence of glibenclamide were calculated using Eq. 4. (D) Mean Gm from six experiments in which the mitochondrial KATP channels were inhibited using 5-HD. Under all conditions, Gm recovered fully within 1 min after cessation of AP firing (not depicted). Mean data are presented with every fifth error bar (mean ± SEM).

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal