Figure 4.
Figure 4. IS6-AID linker disruption reduces CDI. (A) Representative netCDI (ICa/IBa) at a test potential of +20 mV for the combinations of the indicated CaV1.2 subunits and CaVβ2a. (B) ti300 values from A. Results of unpaired t tests are indicated as follows: N.S., P > 0.05, not significant; ***, P < 0.001. (C) Isochronal inactivation of CaV1.2 (n = 4, black X’s, netCDI; n = 4, black open squares, VDI), CaV1.2 GGG netCDI (n = 4, gray), and CaV1.2 GGG/HotA netCDI (n = 5, orange). Inactivation extent comparing the ratio of prepulse and test pulse current amplitudes plotted as a function of the test voltage. The pulse protocol is shown at the top. (D) G-V relationships in calcium for the indicated combinations of CaV1.2 subunits and CaVβ2a.

IS6-AID linker disruption reduces CDI. (A) Representative netCDI (ICa/IBa) at a test potential of +20 mV for the combinations of the indicated CaV1.2 subunits and CaVβ2a. (B) ti300 values from A. Results of unpaired t tests are indicated as follows: N.S., P > 0.05, not significant; ***, P < 0.001. (C) Isochronal inactivation of CaV1.2 (n = 4, black X’s, netCDI; n = 4, black open squares, VDI), CaV1.2 GGG netCDI (n = 4, gray), and CaV1.2 GGG/HotA netCDI (n = 5, orange). Inactivation extent comparing the ratio of prepulse and test pulse current amplitudes plotted as a function of the test voltage. The pulse protocol is shown at the top. (D) G-V relationships in calcium for the indicated combinations of CaV1.2 subunits and CaVβ2a.

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