Figure 10.

Magnitude of AA inhibition of β2a-containing channels is independent of fast inactivation. (A) Summary bar graphs of percent inhibition of CaV1.3b currents with β2a (from Fig. 3 A for comparison), β2e, depalmitoylated β2a C3,4S, and depalmitoylated β2a C3,4S-CD8 (n = 6–9; *, P < 0.05 compared with β2a). (B) The amount of inactivation, measured as r40, for β2e, depalmitoylated β2a C3,4S, and depalmitoylated β2a C3,4S-CD8 before (CTL) and after a 1-min exposure to AA. (C) Representative current traces from CaV1.3b coexpressed with β2e, depalmitoylated β2a C3,4S, and depalmitoylated β2a C3,4S-CD8. (Left) Before (black) and after a 1-min exposure to AA (dark gray). (Right) Normalized to the end of the 40-ms test pulse. Bars, 1 nA, 10 ms.

or Create an Account

Close Modal
Close Modal