CaV1.3b kinetic changes by AA are not due to a shift in voltage sensitivity. (A and B) Summary of average current remaining at the end of a 40-ms test pulse (r40) for currents before (open bars, CTL) or after a 1-min exposure to 10 µM AA (filled bars) from a holding potential of −90 mV (A) or −60 mV (B; n = 7–17; *, P < 0.05). (C) TTP for CTL (filled circles) or AA (open circles) currents across voltages where channels are activated from a holding potential of −60 mV (n = 7–13; *, P < 0.05). (D) Summary of TTP changes produced by 30 µM ETYA (open bars, CTL before ETYA; gray bars, 1 min after ETYA; blue bar, 1 min after 30 µM ETYA + 10 µM AA for β3; n = 4–8; *, P < 0.05). (E) Summary of r40 changes produced by ETYA. Bar descriptions are the same as in D.
