Figure 2.
Figure 2. CaV1.3b current inhibition and kinetic changes by AA are CaVβ subunit dependent. (A) Representative current traces from CaV1.3b channels coexpressed with β1b, β2a, β3, or β4 before (CTL; black line) or 1 min after AA (10 µM; red line) application highlight the smaller amount of inhibition with β2a. (B) Current traces from A were normalized to the end of the test pulse to highlight kinetic changes produced by AA for β1b-, β3-, and β4-, but not β2a-containing channels. (C) Inhibited currents were averaged and subtracted from averaged CTL currents to obtain a difference current for CaV1.3b with each CaVβ subunit to determine the shape of the current lost after AA application (n = 7–13).

CaV1.3b current inhibition and kinetic changes by AA are CaVβ subunit dependent. (A) Representative current traces from CaV1.3b channels coexpressed with β1b, β2a, β3, or β4 before (CTL; black line) or 1 min after AA (10 µM; red line) application highlight the smaller amount of inhibition with β2a. (B) Current traces from A were normalized to the end of the test pulse to highlight kinetic changes produced by AA for β1b-, β3-, and β4-, but not β2a-containing channels. (C) Inhibited currents were averaged and subtracted from averaged CTL currents to obtain a difference current for CaV1.3b with each CaVβ subunit to determine the shape of the current lost after AA application (n = 7–13).

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