Figure 2.
Figure 2. Glycine mutations in IIS6 differentially modulate CaV1.2 gating. (A) Representative tail currents of wild-type, A780G, and I781G channels. Currents were activated during a 20-ms conditioning depolarization to 0 mV for wild-type, −10 mV for A780P, and −30 mV for I781G. Deactivation was recorded during subsequent repolarizations (10-mV increments) starting from −100 mV. (B) Voltage dependences of steady-state activation of the indicated glycine mutants.

Glycine mutations in IIS6 differentially modulate CaV1.2 gating. (A) Representative tail currents of wild-type, A780G, and I781G channels. Currents were activated during a 20-ms conditioning depolarization to 0 mV for wild-type, −10 mV for A780P, and −30 mV for I781G. Deactivation was recorded during subsequent repolarizations (10-mV increments) starting from −100 mV. (B) Voltage dependences of steady-state activation of the indicated glycine mutants.

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