Figure 3. Unitary properties of ClC-4 in intracellular I− and extracellular SCN−. (A) Averaged power spectrum of ClC-4 currents from 30 sweeps after correction for background noise at −115 or +135 mV. Lines represent fits with a second-order Lorentzian function. Blue crosses depict a representative power spectrum from a nontransfected HEK293 cell in extracellular SCN−. (B) Representative time course of ClC-4 mean currents and variances used for nonstationary noise analysis. (C) Current–variance plot (top panel) and linear transformation of the data (bottom panel) for the cell given in B. Red lines represent the fit with standard parabolic function (top panel) or a linear fit (bottom panel). (D) Representative ClC-4 current responses to a voltage ramp between −300 and +400 mV. Current amplitudes were normalized to the value at +150 mV.
Figure 3.

Unitary properties of ClC-4 in intracellular I− and extracellular SCN−. (A) Averaged power spectrum of ClC-4 currents from 30 sweeps after correction for background noise at −115 or +135 mV. Lines represent fits with a second-order Lorentzian function. Blue crosses depict a representative power spectrum from a nontransfected HEK293 cell in extracellular SCN−. (B) Representative time course of ClC-4 mean currents and variances used for nonstationary noise analysis. (C) Current–variance plot (top panel) and linear transformation of the data (bottom panel) for the cell given in B. Red lines represent the fit with standard parabolic function (top panel) or a linear fit (bottom panel). (D) Representative ClC-4 current responses to a voltage ramp between −300 and +400 mV. Current amplitudes were normalized to the value at +150 mV.

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