Figure 8.
Figure 8. GlyH-101 blocks the poststimulation current in HEK cells coexpressing SLC26A9 and wtCFTR. Cells were stimulated with 10 µM forskolin for 3 min, and then perfused with bath alone for an additional 3 min to expose the poststimulation current. After the poststimulation current had stabilized, 50 µM GlyH-101 was added for 3 min, after which cells slowly recovered from blocker. The effect of GlyH-101 was similar to its effect on cells expressing SLC26A9 alone (Fig. 4 A). VH = −40 mV, and currents are normalized to cell capacitance. A representative tracing of three experiments is shown.

GlyH-101 blocks the poststimulation current in HEK cells coexpressing SLC26A9 and wtCFTR. Cells were stimulated with 10 µM forskolin for 3 min, and then perfused with bath alone for an additional 3 min to expose the poststimulation current. After the poststimulation current had stabilized, 50 µM GlyH-101 was added for 3 min, after which cells slowly recovered from blocker. The effect of GlyH-101 was similar to its effect on cells expressing SLC26A9 alone (Fig. 4 A). VH = −40 mV, and currents are normalized to cell capacitance. A representative tracing of three experiments is shown.

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