Effects of C0C2 on rates of tension redevelopment (k_tr). (A) Smoothed force traces showing steady-state force measurements after a release and restretch maneuver (k_tr) during maximal Ca²⁺ activation (pCa 4.5) and during submaximal Ca²⁺ activation (pCa 5.4). Incubation with 5 μM C0C2 accelerated k_tr at low Ca²⁺ (pCa 5.8) to near maximal rates. (B) 5 μM C0C2 accelerated k_tr at all levels of submaximal Ca²⁺ activation.