Figure 1.
Figure 1. Inhibition of pacemaker (If) current does not inhibit spontaneous calcium signals of embryonic cardiomyocytes. (A) Representative recording showing the effect of 10 μM Zeneca on the If (bottom left) elicted by hyperpolarization of the embryonic cardiomyocyte membrane from −50 to −120 mV in whole cell voltage clamp (top left) and the current–voltage relationship of the If current with and without Zeneca (right). (B) Spontaneous calcium signals recorded from E10 cardiomyocytes before (left) and after application of the pacemaker current inhibitor Zeneca ZD7288 (right), and the effect on the frequency (C) and amplitude (D) of the calcium signals.

Inhibition of pacemaker (If) current does not inhibit spontaneous calcium signals of embryonic cardiomyocytes. (A) Representative recording showing the effect of 10 μM Zeneca on the If (bottom left) elicted by hyperpolarization of the embryonic cardiomyocyte membrane from −50 to −120 mV in whole cell voltage clamp (top left) and the current–voltage relationship of the If current with and without Zeneca (right). (B) Spontaneous calcium signals recorded from E10 cardiomyocytes before (left) and after application of the pacemaker current inhibitor Zeneca ZD7288 (right), and the effect on the frequency (C) and amplitude (D) of the calcium signals.

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