Contribution of ADAR to tissue-specific editing patterns. The top panel shows quantitation of RNA editing levels in head samples for sites 1–4 from isoform profiling (Profile), direct RT-PCR sequence analysis (see Materials and methods), wild-type (CS), and direct RT-PCR sequence analysis from dADAR-null animals rescued with a single dADAR isoform expressed pan-neuronally. The bottom panel shows quantitation of RNA editing levels in wing samples, as in the top panel.