A summary of conductance simulations and comparison with experiments. (A) Simulated I-V curve obtained without the cage domain (open circles), and curve position adjusted to represent the entire channel including the estimated resistance of the cytoplasmic cage (filled circles). The simulated curves can be compared with experimental I-V curves obtained on single channels (filled triangles) and multichannel patches (open triangles). The horizontal axis shows pipette voltages with positive branch representing hyperpolarizations. Note that measurements on multichannel patches allowed to explore a wider range of voltages (open triangles, see Fig. 7 and legend for technical details). (B) The ratio of Cl⁻ to K⁺ ions occupying the gate region of the pore (triangles) and the fraction of current carried by Cl⁻ simulated at different transmembrane voltages (diamonds). (C) Electroosmotic water flux associated with Cl⁻ current computed between −200 and +200 mV.