Figure 6.
Figure 6. Current–voltage relationship for the D326N-E329Q mutant and WT BK channel at different K+ concentrations. (A) I-V relation obtained in symmetrical 30 mM K+ for the WT (solid black circles) and the D326N-E329Q mutant (solid red circles). Points are the mean of three to five different experiments ± SD. (B) I-V relation obtained in symmetrical 110 mM K+ for the WT (solid black circles) and the D326N-E329Q mutant (solid red circles). Points are the mean of two to five different experiments ± SD. (C) I-V relation obtained in symmetrical 1,000 mM K+ for the WT (solid black circles) and the D326N-E329Q mutant (solid red circles). Points are the mean of three to six different experiments ± SD. (D) Bar graph of single channel conductance at different K+ for the mutant and for WT. *, P < 0.05; **, P < 0.005.

Current–voltage relationship for the D326N-E329Q mutant and WT BK channel at different K+ concentrations. (A) I-V relation obtained in symmetrical 30 mM K+ for the WT (solid black circles) and the D326N-E329Q mutant (solid red circles). Points are the mean of three to five different experiments ± SD. (B) I-V relation obtained in symmetrical 110 mM K+ for the WT (solid black circles) and the D326N-E329Q mutant (solid red circles). Points are the mean of two to five different experiments ± SD. (C) I-V relation obtained in symmetrical 1,000 mM K+ for the WT (solid black circles) and the D326N-E329Q mutant (solid red circles). Points are the mean of three to six different experiments ± SD. (D) Bar graph of single channel conductance at different K+ for the mutant and for WT. *, P < 0.05; **, P < 0.005.

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