Figure 6.
Figure 6. Characterization of the T15A-P2X7R mutant expressed in HEK293 cells. (A) Patterns of current in response to repetitive application of 100 μM BzATP, followed by a washout period of 5 min. (B and C) 100 μM BzATP-induced biphasic response from cells bathed in NMDG+-KR buffer (B) and NMDG+ buffer (C). (D and E) Lack of channel permeability to NMDG+ (D) and NMEA+ (E) when cells were bathed in KR buffer in which all Na+ was substituted with organic cations. (F) A shift in the reversal potential observed during a 40-s application of 100 μM BzATP from cells bathed in NMDG+ medium.

Characterization of the T15A-P2X7R mutant expressed in HEK293 cells. (A) Patterns of current in response to repetitive application of 100 μM BzATP, followed by a washout period of 5 min. (B and C) 100 μM BzATP-induced biphasic response from cells bathed in NMDG+-KR buffer (B) and NMDG+ buffer (C). (D and E) Lack of channel permeability to NMDG+ (D) and NMEA+ (E) when cells were bathed in KR buffer in which all Na+ was substituted with organic cations. (F) A shift in the reversal potential observed during a 40-s application of 100 μM BzATP from cells bathed in NMDG+ medium.

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