Effects of deletion of the P2X₇R-specific Y358-E375 C-terminal sequence (Δ18) on the pattern of current and permeability to NMDG⁺. (A) Patterns of currents from cells bathed in normal (left) and NMDG⁺-containing KR buffer (right). (B) Changes in the reversal potential during the 40-s application of 100 μM BzATP from cells perfused with NMDG⁺-KR buffer.