Burst analysis of M-Mode activity in α₁β₂γ_2S GABA_ARs. (A) Continuous, 2-s sweeps of single channel activity recorded from a patch expressing α₁β₂γ_2S GABA_AR in response to 10 mM GABA. The break in the recording represents ∼2 min of no activity (“desensitization”). The segment enclosed in the box is expanded below. (B) Dwell time histogram of apparent shut intervals and (C) dwell time histogram of apparent open intervals for the activity shown in A. Distributions were fit with a mixture of exponential probability density functions (dark lines). The individual components are shown as broken lines. The analysis revealed three shut and three open components for this activity. Currents were filtered to 2 kHz for display purposes.