Figure 5.
Figure 5. Genetic epistasis analysis. (A–E) Bone histomorphometric analysis of Crebosb+/−;cMycosb+/− mice at 12 wk of age (controls, n = 15; Crebosb+/−, n = 9; cMycosb+/−, n = 4; Crebosb+/−;cMycosb+/−, n = 8). (F–J) Bone histomorphometric analysis of Adrβ2osb−/−;cMycosb+/− mice at 24 wk of age (controls, n = 11; Adrβ2osb−/−, n = 7; Adrβ2osb−/−;cMycosb+/−, n = 9). *, P < 0.05 between controls; **, P < 0.05 between Adrβ2osb−/− mice and Adrβ2osb−/−;cMycosb+/− mice. Experiments were performed independently twice, and representative data are shown. Results are shown as mean ± SEM. Dashed lines indicate control value of 100%. BV/TV, bone volume over tissue volume; Ob.Nb/T.Ar, number of osteoblasts per trabecular area; Oc.S/T.Ar, osteoclast surface per trabecular area.

Genetic epistasis analysis. (A–E) Bone histomorphometric analysis of Crebosb+/−;cMycosb+/− mice at 12 wk of age (controls, n = 15; Crebosb+/−, n = 9; cMycosb+/−, n = 4; Crebosb+/−;cMycosb+/−, n = 8). (F–J) Bone histomorphometric analysis of Adrβ2osb−/−;cMycosb+/− mice at 24 wk of age (controls, n = 11; Adrβ2osb−/−, n = 7; Adrβ2osb−/−;cMycosb+/−, n = 9). *, P < 0.05 between controls; **, P < 0.05 between Adrβ2osb−/− mice and Adrβ2osb−/−;cMycosb+/− mice. Experiments were performed independently twice, and representative data are shown. Results are shown as mean ± SEM. Dashed lines indicate control value of 100%. BV/TV, bone volume over tissue volume; Ob.Nb/T.Ar, number of osteoblasts per trabecular area; Oc.S/T.Ar, osteoclast surface per trabecular area.

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