A schematic model of osteoclastogenesis regulated by the Blimp1-Bcl6-osteoclastic gene axis. RANKL–RANK interaction results in Blimp1 induction, leading to Bcl6 down-regulation and dissociation of Bcl6 from osteoclastic gene promoters, an event critical for osteoclastogenesis. NFATc1 activation is induced by various factors, such as ITAM, TRAF6, c-Fos, and Ca²⁺ signaling, which are also activated by RANKL.