Figure 1. Induction of erosive primary skin lesions in VACV-infected eczematous mice. (A) Eczematous skin lesions were induced by repeated Der f/SEB (D/B) treatments, and mice with a clinical score of ≥8 were infected intradermally with VACV (eczematous group). A cohort (normal group) of mice with healthy skin was also infected at the same anatomical site. (B) Typical eczematous (right) and normal (left) mice are shown on day 6 after infection. (C) The size of erosive skin lesions. Shown is a representative of at least 15 experiments using 4–10 mice in each group. (D) Virus titers in the infected skin (n = 7 mice per group). Shown are results representative of four independent experiments. Data represent means and SEM values. *, P < 0.05; **, P < 0.01; and ***, P < 0.001 versus normal mice. ND, not detected.
Figure 1.

Induction of erosive primary skin lesions in VACV-infected eczematous mice. (A) Eczematous skin lesions were induced by repeated Der f/SEB (D/B) treatments, and mice with a clinical score of ≥8 were infected intradermally with VACV (eczematous group). A cohort (normal group) of mice with healthy skin was also infected at the same anatomical site. (B) Typical eczematous (right) and normal (left) mice are shown on day 6 after infection. (C) The size of erosive skin lesions. Shown is a representative of at least 15 experiments using 4–10 mice in each group. (D) Virus titers in the infected skin (n = 7 mice per group). Shown are results representative of four independent experiments. Data represent means and SEM values. *, P < 0.05; **, P < 0.01; and ***, P < 0.001 versus normal mice. ND, not detected.

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