Figure 1. Soluble NKp30-Fc inhibits NK-92 cytolysis and binds K562 cells. (A) Soluble NKp30-Fc inhibited the killing of K562 cells by NK-92 cells. A 4-h cytoxicity assay was performed in the presence (thin line) or absence (bold line) of 2 µg/ml NKp30-Fc. Data indicate the mean of triplicates ± SD and are representative of three independent experiments. (B) Soluble NKp30-Fc binds K562. The binding of NKp30-Fc to K562 cells was measured by flow cytometry in the presence of blocking anti-NKp30 F(ab′)2 mAb (AZ20, IgG1) or a negative control anti-NKp46 F(ab′)2 mAb (BAB281, IgG1). Data are representative of at least three independent experiments.
Figure 1.

Soluble NKp30-Fc inhibits NK-92 cytolysis and binds K562 cells. (A) Soluble NKp30-Fc inhibited the killing of K562 cells by NK-92 cells. A 4-h cytoxicity assay was performed in the presence (thin line) or absence (bold line) of 2 µg/ml NKp30-Fc. Data indicate the mean of triplicates ± SD and are representative of three independent experiments. (B) Soluble NKp30-Fc binds K562. The binding of NKp30-Fc to K562 cells was measured by flow cytometry in the presence of blocking anti-NKp30 F(ab′)2 mAb (AZ20, IgG1) or a negative control anti-NKp46 F(ab′)2 mAb (BAB281, IgG1). Data are representative of at least three independent experiments.

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