CXP lymphomas harbor normal V(D)J rearrangements in IgH locus. Nucleotide sequence analysis of primary V_H(D)J_H rearrangements cloned from the following: CXP153 by both λ-phage library and PCR (A); CXP163 by λ-phage library (B); CXP68 by PCR (C); and CXP2152 by PCR (D). Additional sequence analyses revealed that CXP153 had a productive V7183-D-JH2 rearrangement juxtaposed into to the first intron of c-myc and CXP163 has a nonproductive VH12-D-JH2 rearrangement juxtaposed to the sequence upstream of c-myc exon1. V regions are shown in blue and J regions in red. The open reading frame is indicated under the DNA sequence. PCR analyses were performed at least three times from one or multiple independent tumor DNA samples. PCR fragments were subcloned into pGEM vector, 10–20 subclones were sequenced, and identical rearrangements observed in >80% clones were scored as clonal rearrangements.