Figure 5. Spontaneous development of a fulminant form of neuropathy in NOD-RAGKO-POT mice. (A) Quantification of infiltration in the nerves of indicated mice at 3–4 wk of age. Horizontal bars indicate means. *, P < 0.05. (B) Weight in the indicated mice as a function of age. Results represent cumulated data from two different experiments. Data are means ± SEM. (C) Clasping phenotype in a representative NOD-RAGKO-POT mouse compared with the normal plantar reaction in a NOD-RAGKO littermate, and weight deficit in NOD-RAGKO-POT mice at 3–4 wk of age. (D) Neuropathy in the indicated mice as a function of age. (E) Intense infiltrate in the sciatic nerve of NOD-RAGKO-POT mice. Bars, 250 µm. (F) Adoptive transfer of neuropathy by spleen cells from NOD-RAGKO-POT mice into NOD-SCID recipients (n = 4). Data are representative of two independent transfers. Videos 1–3 are available at http://www.jem.org/cgi/content/full/jem.20082113/DC1.
Figure 5.

Spontaneous development of a fulminant form of neuropathy in NOD-RAGKO-POT mice. (A) Quantification of infiltration in the nerves of indicated mice at 3–4 wk of age. Horizontal bars indicate means. *, P < 0.05. (B) Weight in the indicated mice as a function of age. Results represent cumulated data from two different experiments. Data are means ± SEM. (C) Clasping phenotype in a representative NOD-RAGKO-POT mouse compared with the normal plantar reaction in a NOD-RAGKO littermate, and weight deficit in NOD-RAGKO-POT mice at 3–4 wk of age. (D) Neuropathy in the indicated mice as a function of age. (E) Intense infiltrate in the sciatic nerve of NOD-RAGKO-POT mice. Bars, 250 µm. (F) Adoptive transfer of neuropathy by spleen cells from NOD-RAGKO-POT mice into NOD-SCID recipients (n = 4). Data are representative of two independent transfers. Videos 1–3 are available.

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